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(2R)-1,1-difluoro-2-palmitoyloxy-3-phosphopropane (XY-4)


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Catalog No.:  L-1160
MW: 430.46
CAS: 474329-47-0

Description:  XY-4 is an analog of 2-palmitoyl lysophosphatidic acid (LPA) in which the sn-1 hydroxyl has been replaced by two fluorines. It acts as a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ) but does not stimulate LPA1, LPA2, or LPA3 receptors. PPARγ is a transcription factor of the nuclear receptor superfamily and has been implicated in atherogenesis.

Storage

-20 °C

Featured in Publications

1) Zhang, C., D. L. Baker, et al. (2004). "Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation." The Journal of Experimental Medicine 199(6): 763-774.
2) McIntyre, T. M., A. V. Pontsler, et al. (2003). "Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist." Proceedings of the National Academy of Sciences 100(1): 131-136.


Options/Sizes Pricing
L-1160-0.5mg $ 120.00
Additional Information:
Tech Data Sheet - L-1160


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assay and reagents for drug discovery in lipid signaling pathways