Products

LPA Beads


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Catalog No.:  L-6101

Description:  LPA beads are composed of agarose with 10 nanomoles of bound Lyosphosphatidic Acid (LPA) per mL of beads, enough for several protein binding experiments. Each 1 mL order of LPA Beads includes a small amount of control beads. Larger quantities of Control Beads are also available for purchase.

Storage

4 °C - do not freeze

Applications

LPA Beads are designed for use in protein pull-down experiments to identify and characterize LPA binding proteins. Possible applications include the isolation of lipid-binding proteins present in a cell lysate or in a mixture of in vitro translated peptides, for separation by SDS-PAGE and further analysis.

Featured in Publications

1) 1. A. S. Nieto-Posadas, G. Picazo-Juárez, et al. (2012) "Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site" Nat Chem Biol 8(1), 78-85 doi:10.1038/nchembio.712
2) R. Tsukahara, H. Haniu, et al. (2014) "Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells" FEBS Open Bio 4(1), 947-951 DOI: 10.1016/j.fob.2014.10.014
3) S. L. Morales-Lazaro, B. Serrano-Flores, et al. (2014) "Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs" J. Biol. Chem. 289(35), 24079-24090 10.1074/jbc.M114.572503

Being bio-reactive blog: "Lipid-Ligand interaction tools: lipids are not scary intermediates anymore"


Options/Sizes Pricing
L-6101-0.1ml $ 108.00
L-6101-1ml $ 509.00
Additional Information:
Tech Data Sheet - TDS_P-Bxxx_ Rev 7


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assay and reagents for drug discovery in lipid signaling pathways