(S,S) Bisoleoyl-lysobisphosphatidic acid (LBPA)
Catalog No.: L-B181
Description: Lysobisphosphatidic acids (LBPAs), known also as bis-(monoacylglycerol)phosphates (BMPs) are specialized lipids reported to play a role in intracellular protein and lipid transport in healthy cells. Their accumulation was observed in pathologic liver tissue, and they also serve as antigens for auto-antibody generation in a human autoimmune condition termed antiphospholipid syndrome. Accumulation of LBPAs in intracellular, often multilamellar membranes is related to biomembrane polymorphism which may impact intracellular cholesterol transport.
(S,S) Bisoleoyl-lysobisphosphatidic acid is the naturally occurring, biologically activie isomer of LPBA.
SolubilityMeOH:CHCl3 (1:1 v/v) > 1mg/mL
Featured in Publications:1) Abe, A, Shayman, J.A. (2009) "The role of negatively charged lipids in lysosomal phospholipase A2 function." Journal of Lipid Research. 50(10): 2027-35.
2) Chevallier, J. et al. (2008) "Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels" Journal of Biological Chemistry. 283: 27871-27880
3) Yang, S-T. et al (2010) "Cell-Penetrating Peptide Induces Leaky Fusion of Liposomes Containing Late Endosome-Specific Anionic Lipid" Biophysical Journal. 8(20): 2525–2533
4) Alvira, D. et al. (2011) "Inhibition of Protein-tyrosine Phosphatase 1B (PTP1B) Mediates Ubiquitination and Degradation of Bcr-Abl Protein" Journal of Biological Chemistry. 286: 32313-32323.
5) Bissig, C. et al. (2013) "Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX" Cell. 25(4): 364-373.
Related Products:Anti-LBPA Antibody (6C4) (Z-SLBPA)
Purified Anti-LBPA Antibody (6C4) (Z-PLBPA)
Biotin-(R,R)-2,2’-Bisdodecyl-LBPA (biotin-C12-ether LBPA) (L-B1B12)
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Tech Data Sheet - L-B181
assay and reagents for drug discovery in lipid signaling pathways