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Sphingosine Kinase Inhibitor (SKI-II)


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Catalog No.:  B-0024
MW: 339.2
Purity: 97%
CAS: 312636-16-1

Description:  2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins.

Solubility

  • DMSO


Options/Sizes Pricing
B-0024-10mg $ 64.00
B-0024-50mg $ 298.00
Additional Information:
Tech Data Sheet - B-0024


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assay and reagents for drug discovery in lipid signaling pathways