Products

Purified Anti-PtdIns(3,4)P2 IgG


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Catalog No.:  Z-P034b

Description:  Purified Anti-PtdIns(3,4)P2 antibody
Subtype: IgG3
Source: Mouse
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay

Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Bae, Y. H., Z. Ding, et al. (2010). "Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells." Proceedings of the National Academy of Sciences.

Related Products

Biotinylated Anti-PtdIns(3,4)P2 IgG (Z-B034b)
Phosphatidylinositol 3,4-bisphosphate, diC8 (P-3408)
Phosphatidylinositol 3,4-bisphosphate, diC16 (P-3416)


Options/Sizes Pricing
Z-P034b-10ug $ 134.00
Z-P034b-50ug $ 370.00
Z-P034b-250ug $ 1,296.00
Additional Information:
Protocol - Protocol for immunofluorescence in chamber slides

Protocol b - Protocol for frozen tissue sections

Tech Data Sheet - Z-P034b


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assay and reagents for drug discovery in lipid signaling pathways