Products

Anti-PtdIns(3,4,5)P3 IgM In Ascities

 
Catalog No.:  Z-A345

Description:  Anti-PtdIns(3,4,5)P3 monoclonal antibody in ascites.
Subclass: IgM
Source: Mouse
Applications: ELISA, Immunofluorescence

Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Chen, R., V. H. Kang, et al. (2002). "A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells." J Histochem Cytochem 50(5): 697-708.
2) Weiner, O. D., P. O. Neilsen, et al. (2002). "A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity." Nat Cell Biol 4(7): 509-13.
3) Silva, A., J. A. Yunes, et al. (2008). "PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability." J Clin Invest 118(11): 3762-74.
4) Shearn, C. T., R. L. Smathers, et al. (2011). "Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes." Mol Pharmacol 79(6): 941-52.

Related Products

Purified Anti-PtdIns(3,4,5)P3 IgM (Z-P345)
Biotinylated Anti-PtdIns(3,4,5)P3 IgM (Z-B345)
Fluorescein conjugated Anti-PI(3,4,5)P3 IgM (Z-G345)
Anti-PtdIns(3,4,5)P3 IgM HRP (Z-H345)
Purified Anti-PtdIns(3,4,5)P3 IgG (Z-P345b)

Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3


Options/Sizes Pricing
Z-A345-100ug $ 249.00
Z-A345-200ug $ 400.00
Z-A345-500ug $ 923.00
Additional Information:
Tech Data Sheet - Z-A345

Protocol - Protocol for immunofluorescence in chamber slides

Protocol - Protocol for frozen tissue sections


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assay and reagents for drug discovery in lipid signaling pathways