Products

Anti-PtdIns(3,4,5)P3 IgM HRP

 
Catalog No.:  Z-H345

Description:  Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody conjugated with horseradish peroxidase.
Subclass: IgM
Source: Mouse
Applications: ELISA, Immunofluorescence

Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Garcia-San Frutos, M., T. Fernandez-Agullo, et al. (2007). "Impaired central insulin response in aged Wistar rats: role of adiposity." Endocrinology 148(11): 5238-47.

Related Products

Purified Anti-PtdIns(3,4,5)P3 IgM (Z-P345)
Biotinylated Anti-PtdIns(3,4,5)P3 IgM (Z-B345)
Fluorescein conjugated Anti-PI(3,4,5)P3 IgM (Z-G345)
Purified Anti-PtdIns(3,4,5)P3 IgG (Z-P345b)

Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3


Options/Sizes Pricing
Z-H345-10ug $ 207.00
Z-H345-50ug $ 393.00
Z-H345-250ug $ 1,043.00
Additional Information:
Tech Data Sheet - Z-H345

Protocol - Protocol for immunofluorescence in chamber slides

Protocol - Protocol for frozen tissue sections


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assay and reagents for drug discovery in lipid signaling pathways