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PTEN Enzyme


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Catalog No.:  E-3000

Description:  N-Terminal GST-Tagged, recombinent human PTEN (Phosphatase and Tensin Homolog), 76kD, purified from E.coli using glutathione-sepharose column
chromatography.

PTEN is a 3-phosphoinositide phosphatase that converts PI(3,4,5)P3 to PI(4,5)P2; thus opposing PKB/Akt activation by PI3-K. PTEN is involved in neuronal stem cell proliferation and self-renewal, cardiac myocyte hypertrophy and contractility, and a wide range of developmental processes. PTEN, however, is best known for its role as a tumor suppressor. Loss of PTEN activity results in accumulation of PI(3,4,5)P3, abnormal activation of PKB/Akt, unregulated cell growth, suppression of apoptosis, and increase tumorigenesis in a number of human tissues. It has also been proposed that PTEN is a candidate for targeted chemotherapy because certain anti-cancer agents preferentially destroy tumors with PTEN mutations. In addition to this direct role in cancer, PTEN also indirectly regulates cancer-associated pathways including VEGF-mediated angiogenesis among others.

Storage:

-70 °C

Related Products:

PTEN Activity ELISA (K-4700)
Malachite Green Assay Kit (K-1500)

PTEN Substrates: P-3908, P-3916, Q-1345
SF1670 (PTEN Inhibitor) <(B-0350)
Other Lipid Phosphatases: SHIP2 (E-1000), INPP4A (E-8000)


Options/Sizes Pricing
E-3000-2.5ug $ 85.00
E-3000-10ug $ 279.00
Additional Information:
Tech Data Sheet - TDS_E-3000_Rev7x


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assay and reagents for drug discovery in lipid signaling pathways