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SHIP2 Enzyme


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Catalog No.:  E-1000

Description:  SH2-containing 5`-inositol phosphatase 2 (SHIP2) is a lipid phosphatase which converts PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance. SHIP2 down-regulates insulin signaling and is present at higher levels in diabetes and obesity. Abnormalities in SHIP function are increasingly linked to disease, in particular in the role of SHIP as a negative regulator of cytokine and immune receptor signalling.

Storage:

-70 °C

Featured in Publications:

1) Drees, B. E., A. Weipert, et al. (2003). "Competitive fluorescence polarization assays for the detection of phosphoinositide kinase and phosphatase activity." Comb Chem High Throughput Screen 6(4): 321-30.
2) Brooks, R., G. M. Fuhler, et al. (2010). "SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells." J Immunol 184(7): 3582-9.

Related Products:

Malachite Green Assay Kit: K-1500
5’ PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay K-1400
SHIP2 Substrates: P-3908, P-3916
Other related enzymes: PTEN (E-3000), PI3K alpha (E-2000), INPP4A (E-8000)


Options/Sizes Pricing
E-1000-10ug $ 358.00
E-1000-100ug $ 2,201.00
Additional Information:
Tech Data Sheet - TDS E-1000 SHIP2 Rev 3


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assay and reagents for drug discovery in lipid signaling pathways