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Phosphatidylinositol 3,4-bisphosphate diC4 (PI(3,4)P2 diC4)


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Catalog No.:  P-3404
MW: 744.26

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Storage

-20°C

Featured in Publications

1) Stampoulis, P., T. Ueda, et al. (2012). "Atypical membrane-embedded PI(3,4)P2 binding site on p47phox PX domain revealed by NMR." J Biol Chem(287): 17848-17859.


Options/Sizes Pricing
P-3404-100ug $ 110.00
P-3404-250ug $ 225.00
P-3404-500ug $ 375.00
P-3404-1mg $ 675.00

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assay and reagents for drug discovery in lipid signaling pathways