Phosphatidylinositol 3,4-bisphosphate diC4 (PI(3,4)P2 diC4)

Catalog No.:  P-3404
MW: 744.26

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.



Featured in Publications

1) Stampoulis, P., T. Ueda, et al. (2012). "Atypical membrane-embedded PI(3,4)P2 binding site on p47phox PX domain revealed by NMR." J Biol Chem(287): 17848-17859.

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Product Keywords: Dibutanoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 C4, PI(3,4)P2 C4, or PI34P2.

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Options/Sizes Pricing
P-3404-100ug $ 116.00
P-3404-500ug $ 394.00
P-3404-1mg $ 709.00
Additional Information:
Tech Data Sheet - P-3404

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assay and reagents for drug discovery in lipid signaling pathways