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Phosphatidylinositol 3,4-bisphosphate diC8 (PI(3,4)P2 diC8)


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Catalog No.:  P-3408
MW: 856.48
CAS: 188885-38-3

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Storage

  • -20° C

Featured in Publication:

1) Elge, S., C. Brearley, et al. (2001). "An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors." Plant J 26(6): 561-71.
2) Tong, Q., N. Gamper, et al. (2004). "Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase." J Biol Chem 279(21): 22654-63.

Product Keywords: Dioctanoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2, PI(3,4)P2, or PI34P2.

Bulk discounts available, please email echelon@echelon-inc.com for details.


Options/Sizes Pricing
P-3408-100ug $ 45.00
P-3408-500ug $ 218.00
P-3408-1mg $ 390.00
Additional Information:
PIP FAQs - PIP FAQ's

Tech Data Sheet - P-3408 TDS


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assay and reagents for drug discovery in lipid signaling pathways