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Phosphatidylinositol 3,4-bisphosphate diC16 (PI(3,4)P2 diC16)


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Catalog No.:  P-3416
MW: 1080.9
CAS: 183623-41-8

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Storage

-20° C

Featured in Publication:

1) Dowler, S., R. A. Currie, et al. (1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides." Biochem J 342(Pt 1): 7-12.
2) Karathanassis, D., R. V. Stahelin, et al. (2002). "Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4- bisphosphate and phosphatidic acid is masked by an intramolecular interaction." Embo J 21(19): 5057-68.
3) Stampoulis, P., T. Ueda, et al. (2012). "Atypical membrane-embedded PI(3,4)P2 binding site on p47phox PX domain revealed by NMR." J Biol Chem(287): 17848-17859.

Product Keywords: Dioctanoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2, PI(3,4)P2, or PI34P2.

Bulk discounts available, please email echelon@echelon-inc.com for details.


Options/Sizes Pricing
P-3416-100ug $ 60.00
P-3416-500ug $ 218.00
P-3416-1mg $ 390.00
Additional Information:
PIP FAQs - PIP FAQ's

Tech Data Sheet - P-3416 TDS


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assay and reagents for drug discovery in lipid signaling pathways