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Phosphatidylinositol 3,5-bisphosphate diC4 (PI(3,5)P2 diC4)


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Catalog No.:  P-3504

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).

Storage

-20°C

Featured in Publications:

1) He, F., M. Mao, et al. (2004). "Enhancement of phototransduction g protein-effector interactions by phosphoinositides." J Biol Chem 279(10): 8986-90.
2) Fernandes, F., K. Chen, et al. (2011). "Phosphoinositides direct equine infectious anemia virus gag trafficking and release." Traffic 12(4): 438-51.
3) Pylypenko, O., R. Lundmark, et al. (2007). "The PX-BAR membrane-remodeling unit of sorting nexin 9." EMBO J 26(22): 4788.

Product Keywords: Dibutanoyl Phosphatidylinositol 3,5-bisphosphate, PtdIns(3,5)P2, PI(3,5)P2

Bulk discounts available, please email echelon@echelon-inc.com for information.


Options/Sizes Pricing
P-3504-100ug $ 114.00
P-3504-500ug $ 390.00
P-3504-1mg $ 702.00
Additional Information:
Tech Data Sheet - TDS_P-3504, P-3508, P-3516_ Rev 7


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assay and reagents for drug discovery in lipid signaling pathways