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Phosphatidylinositol 3,4,5-trisphosphate diC4 (PI(3,4,5)P3 diC4)


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Catalog No.:  P-3904
MW: 868.21
CAS: 163563-77-7

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

<-20 °C

Featured in Publications

1) Thapar, R., A. E. Karnoub, et al. (2002). "Structural and biophysical insights into the role of the insert region in Rac1 function." Biochemistry 41(12): 3875-83.
2) He, J., R. M. Haney, et al. (2008). "Molecular mechanism of membrane targeting by the GRP1 PH domainboxs." J Lipid Res 49(8): 1807-15.
3) Lumb, C. N., J. He, et al. (2011). "Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain." Structure 19(9): 1338-46.

Product Keywords: Dibutanoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3, PI(3,4,5)P3, or PIP3

Bulk discounts available, please email echelon@echelon-inc.com for information.


Options/Sizes Pricing
P-3904-100ug $ 47.00
P-3904-500ug $ 218.00
P-3904-1mg $ 390.00
Additional Information:
Tech Data Sheet - TDS_P-3904_Rev 6


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assay and reagents for drug discovery in lipid signaling pathways