Phosphatidylinositol 4,5-bisphosphate diC4 (PI(4,5)P2 diC4)

Catalog No.:  P-4504
MW: 744.26

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K).


-20 °C

Featured in Publications:

1) Campbell, R. B., F. Liu, et al. (2003). "Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate." J Biol Chem 278(36): 33617-20.
2) Feng, J., M. F. Roberts, et al. (2005). "Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits." Biochemistry 44(7): 2577-84.
3) Luo, R., L. M. Miller Jenkins, et al. (2008). "Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activity." Cellular Signalling 20(11): 1968.
4) Li, Y., M. A. Zaydman, et al. (2011). "KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity." Proceedings of the National Academy of Sciences 108(22): 9095-9100.
5) A. L. Egea-Jimenez, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. M. Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau and P. Zimmermann. (2016) "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling" Nat Commun 7, DOI: 10.1038/ncomms12101

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Product Keywords: Dibutanoyl Phosphatidylinositol 4,5-bisphosphate, PtdIns(4,5)P2 C4, PI(4,5)P2 C4, or PIP2

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Options/Sizes Pricing
P-4504-100ug $ 102.00
P-4504-500ug $ 313.00
P-4504-1mg $ 540.00
Additional Information:

Tech Data Sheet - P-4504 TDS

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assay and reagents for drug discovery in lipid signaling pathways