Phosphatidylinositol 5-phosphate diC4 (PI(5)P diC4)

Catalog No.:  P-5004
MW: 620.32

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases.


-20 °C

Featyred in Publications:

1) Guo, J., M. R. Wenk, et al. (2003). "Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles." Proc Natl Acad Sci U S A 100(7): 3995-4000.
2) Pendaries, C., H. Tronchere, et al. (2006). "PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection." Embo J 25(5): 1024-34.
3) Ramel, D., F. Lagarrigue, et al. (2011). "Shigella flexneri Infection Generates the Lipid PI5P to Alter Endocytosis and Prevent Termination of EGFR Signaling." Sci. Signal. 4(191): ra61-.
4) Boal, F. d. r., A. Puhar, et al. (2016). "PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment." Cell Reports., doi:10.1016/j.celrep.2015.12.079

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Product Keywords: Dibutanoyl Phosphatidylinositol 5-phosphate, PtdIns(5)P C4, PI(5)P C4, or PI5P

Bulk discounts available, please email for information.

Options/Sizes Pricing
P-5004-100ug $ 102.00
P-5004-500ug $ 313.00
P-5004-1mg $ 540.00
Additional Information:
Tech Data Sheet - TDS_P-5004_Rev 4

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assay and reagents for drug discovery in lipid signaling pathways