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Glycerophosphoinositol 3,4,5-triphosphate (GroPI(3,4,5)P3)


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Catalog No.:  P-3900
MW: 728
CAS: 350685-86-8

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. Glycerophosphoinositol 3,4,5-triphosphate (GroPIP3) is missing the acyl chains from the 1- & 2-positions of the glycerol.

Storage

  • -20 °C


Options/Sizes Pricing
P-3900-100ug $ 99.00
P-3900-500ug $ 303.00
P-3900-1mg $ 524.00
Additional Information:
PIP Faq - PIP FAQ's

Tech Data Sheet - P-3900


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