Products

BODIPY® FL Phosphatidylinositol 3,4,5-trisphosphate


Zoom
 
Catalog No.:  C-39F6
MW: 1795.91
CAS: 911205-85-1

Description:  Water soluble analog of PI(3,4,5)P3 (PIP3) labeled with the green fluorophore, Bodipy®-FL at the sn-1 position.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Excitation/Emission

  • 503/513 nm
  • Storage

    • -20 °C

    Featured in Publications:

    1) Caromile, L. A., A. Oganesian, et al. (2010). "The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion." J Biol Chem 285(14): 10487-96.
    2) Oganesian, A., M. Poot, et al. (2003). "Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation." Proc Natl Acad Sci U S A 100(13): 7563-8.

    Bulk discounts available, please email echelon@echelon-inc.com for information.


    Options/Sizes Pricing
    C-39F6-50ug $ 328.00
    C-39F6-100ug $ 574.00
    Additional Information:
    Tech Data Sheet - C-39F6


    Add a specific quantity to your cart    *  


    Back to the webstore startpage      Back to the product overview      Your Shopping Cart      Terms of Service


    assay and reagents for drug discovery in lipid signaling pathways