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BODIPY® TMR Phosphatidylinositol 3,4,5-trisphosphate


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Catalog No.:  C-39M6
MW: 1987.14

Description:  Water soluble analog of PI(3,4,5)P3 (PIP3) labeled with the orange fluorophore, Bodipy®-TMR, at the sn-1 position.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Excitation/Emission


Options/Sizes Pricing
C-39M6-50ug $ 393.00
C-39M6-100ug $ 676.00
Additional Information:
Tech Data Sheet - C-39M6


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assay and reagents for drug discovery in lipid signaling pathways