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BODIPY® TMR Phosphatidylinositol 4,5-bisphosphate


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Catalog No.:  C-45M6
MW: 1704.78

Description:  Water soluble analog of PI(4,5)P2 (PIP2) labeled with the orange fluorophore, Bodipy®-TMR, at the sn-1 position.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.

Excitation/Emission

542/574 nm

Storage

-20 C

Featured in Publications:

1) Cabanos C, Wang M, Han X, Hansen SB (2017) A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels. Cell Rep 20(6):1287–1294

Bulk discounts available, please email echelon@echelon-inc.com for information.


Options/Sizes Pricing
C-45M6-50ug $ 393.00
C-45M6-100ug $ 676.00
Additional Information:
Tech Data Sheet - C-45M6


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assay and reagents for drug discovery in lipid signaling pathways