Akt Inhibitor (KP372-1)

		Catalog No.:  B-0102 MW: 224.2 Purity: 95% CAS: 329710-24-9 Description:  KP372-1 directly inhibits the kinase activities of Akt, PDK1 and Flt3 (Fms-like tyrosine kinase 3), which are aberrantly activated in acute myelogenous leukemia (AML). It is a cell permeant inhibitor that decreases the colony-forming ability of AML cells (IC50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma.
Solubility Water: insoluble, DMSO: 5 mg/mL Storage dry between 2-8oC. Stock solutions should be stored frozen (-20oC). References 1) M. Mandal et al. "The Akt Inhibitor KP372-1 Suppresses Akt Activity and Cell Proliferation and Induces Apoptosis in Thyroid Cancer Cells" Br. J. Cancer, 2005, 92, 1899-1905. 2) Z. Zeng et al "Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia." Cancer Res., 2006, 66, 3737-3746.
Options/Sizes Pricing B-0102-1mg $ 68.00 B-0102-5mg $ 298.00
Additional Information: Tech Data Sheet - TDS_B-0102_v2
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