Class I PI3-Kinase Reaction Buffer (5X K-KBZ Buffer)

Catalog No.:  K-KBZ

Description:  Use of this kinase reaction buffer improves Class I PI3-Kinase activities for all isoforms. The buffer is compatible with all of our PI3K activity assays (already included with the K-1000s kit) and substrates. Each vial contains 4 mL of 5X buffer.

Class I Phosphoinositide 3-kinases (PI3-K), are ubiquitously expressed lipid kinases which phosphorylate PI(4,5)P2 at the 3'-hydroxyl of the inositol ring producing PtdIns(3,4,5)P3. PtdIns(3,4,5)P3 has shown to be an important lipid second messenger with key roles in fundamental cellular responses such as proliferation and survival. Due to these interesting biological roles, PI3-K and PtdIns(3,4,5)P3 have become attractive targets for research and drug development in many diseases including inflammation and cancer. Echelon has multiple formats available for the determination of class I PI3-K activity.

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K-KBZ-1ea $ 53.00

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assay and reagents for drug discovery in lipid signaling pathways