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IC87114 (PI3-K delta inhibitor)


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Catalog No.:  B-0305
MW: 397.43
Purity: 99%
CAS: 371242-69-2

Description:  IC87114 is a specific inhibitor of PI 3-kinase δ (IC50 = 0.5 μM) with >60-fold selectivity over other isoforms (IC50: α = >100 μM, β = 75 μM, γ = 29 μM). It does not inhibit other protein kinases (p38MAPK, CHK1, cSrc, PKBα, CK1, PKCα, PKCβII) at 10 uM. PI 3-K &delta has an important role in inflammation and inhibition has been shown to impair neutrophil migration. Administration of IC87114 in a mouse asthma model decreased allergic airway inflammation.

Options/Sizes Pricing
B-0305-1mg $ 57.00
B-0305-5mg $ 108.00
B-0305-25mg $ 466.00
Additional Information:
Tech Data Sheet - TDS_B-0305_Rev1


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assay and reagents for drug discovery in lipid signaling pathways