INPP4A, active

Catalog No.:  E-8000

Description:  Human INPP4A with N-terminal 6-His tag was expressed in Sf9 cells and purified using metal chelating chromatography.

INPP4A is a magnesium-independent phosphatase involved in the phosphatidylinositol 3-kinase (PI3K) pathway. INPP4A and its isoenzyme INPP4B hydrolyze the 4 phosphate from the lipid second messenger phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) to form phosphatidylinositol-3-phosphate (PI(3)P). While little evidence supports its role as a tumor suppressor, INPP4A does suppress glutamate excitotoxicity in the central nervous system and is responsible for the Weeble mouse phenotype. A spontaneous frame shift mutation in the Inpp4a gene is present in the Weeble mouse resulting in selective neuronal loss in the cerebellum resulting, severe ataxia and early death.


-70°C or below

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E-8000-2.5ug $ 189.00
Additional Information:
Tech Data Sheet - TDS_ E-8000_Rev2

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assay and reagents for drug discovery in lipid signaling pathways