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[4-(Decanoylamino)benzyl]phosphonic acid (GWJ-23, GWJ-A-23)


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Catalog No.:  L-3223
MW: 385.14
Purity: 98%
CAS: 1351930-95-4

Description:  L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (Ki = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2).

Storage:

-20°C or below.

Featured in Publication:

1) Tager, A.M. (2012) "Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis" Am. J. Resp. Cell Mol. Biol. 47(5): 563-565.
2) Oikonomou, N, M.A. Mouratis, et al. (2012) "Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis." Am. J. Resp. Cell Mol. Biol. 47(5): 566-574.
3) Jiang, G., D. Madan, et al. (2011). "Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin." Bioorganic & Medicinal Chemistry Letters 21(17): 5098.

Related Products:

Autotaxin Inhibitors: BrP-LPA (L-7416), S32826 (L-3282), HA130 (B-0701)
Autotaxin, active (E-4000)
FS-3, Fluorogenic ATX Substrate (L-2000)
ATX-Red AR-2, ATX Imaging Agent (L-2010)
Autotaxin Activity Assay (
K-4100) & Inhibitor Screening Kits (K-4200 and K-4200HTS)


Options/Sizes Pricing
L-3223-1mg $ 33.00
L-3223-5mg $ 150.00
L-3223-10mg $ 265.00
Additional Information:
Tech Data Sheet - L-3223


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assay and reagents for drug discovery in lipid signaling pathways