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3-a-aminocholestane (3AC, SHIP1 Inhibitor)


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Catalog No.:  B-0341
MW: 387.68
Purity: 98%
CAS: 2206-20-4

Description:  SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is only found in hematopoietic lineage cells. 3AC is a selective inhibitor of SHIP1 (EC50 = 10 μM) and shows no inhibition of the other isoform, SHIP2, at concentrations up to 1 mM. 3AC promotes apoptosis of SHIP1-expressing leukemia cells (KG-1) and multiple myeloma cells (OPM) suggesting SHIP1 inhibition is a potential drug target for blood cancers. Mice treated with 3AC show increased numbers of MIR cells in the spleen and lymph nodes and increased numbers of granulocytes.

Storage:

4°C

Featured in References

1) R. Brooks, et al., “SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells” J. Immun., 2010, 184, 3582-3589.
2) .M. Fuhler, et al. “Therapeutic Potential of SH2 Domain-Containing Inositol-5-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer” Mol. Med, 2012, 18, 65-75.
3) Drobek, A., J. Kralova, et al. (2015). "PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk." The Journal of Immunology. DOI:10.4049/jimmunol.1401494

Related Products:

SHIP2, active (E-1000)
SHIP Fluorescence Polarization Assay (K-1400)
Malachite Green Assay Kits (K-1500)
SHIP Substrates: diC8-PI(3,4,5)P3 (P-3908), diC16-PI(3,4,5)P3 (P-3916), Bodipy FL-PI(3,4,5)P3 (C-39F6), Bodipy TMR-PI(3,4,5)P3 (C-39M6)


Options/Sizes Pricing
B-0341-10mg $ 61.00
B-0341-50mg $ 248.00
Additional Information:
Tech Data Sheet - TDS_B-0341_rev1


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assay and reagents for drug discovery in lipid signaling pathways