3-a-aminocholestane (3AC, SHIP1 Inhibitor)

Catalog No.:  B-0341
MW: 387.68
Purity: 98%
CAS: 2206-20-4

Description:  SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is only found in hematopoietic lineage cells. 3AC is a selective inhibitor of SHIP1 (EC50 = 10 μM) and shows no inhibition of the other isoform, SHIP2, at concentrations up to 1 mM. 3AC promotes apoptosis of SHIP1-expressing leukemia cells (KG-1) and multiple myeloma cells (OPM) suggesting SHIP1 inhibition is a potential drug target for blood cancers. Mice treated with 3AC show increased numbers of MIR cells in the spleen and lymph nodes and increased numbers of granulocytes.



Featured in References

1) R. Brooks, et al., “SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells” J. Immun., 2010, 184, 3582-3589.
2) .M. Fuhler, et al. “Therapeutic Potential of SH2 Domain-Containing Inositol-5-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer” Mol. Med, 2012, 18, 65-75.
3) Drobek, A., J. Kralova, et al. (2015). "PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk." The Journal of Immunology. DOI:10.4049/jimmunol.1401494

Related Products:

SHIP2, active (E-1000)
SHIP Fluorescence Polarization Assay (K-1400)
Malachite Green Assay Kits (K-1500)
SHIP Substrates: diC8-PI(3,4,5)P3 (P-3908), diC16-PI(3,4,5)P3 (P-3916), Bodipy FL-PI(3,4,5)P3 (C-39F6), Bodipy TMR-PI(3,4,5)P3 (C-39M6)

Options/Sizes Pricing
B-0341-10mg $ 59.00
B-0341-50mg $ 241.00
Additional Information:
Tech Data Sheet - TDS_B-0341_rev1

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assay and reagents for drug discovery in lipid signaling pathways