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SF1670 (PTEN Inhibitor)


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Catalog No.:  B-0350
MW: 307.34
Purity: 97%
CAS: 345630-40-2

Description:  SF1670 is an inhibitor of PTEN (IC50 = 2 μM). PTEN (Phosphatase and Tensin Homolog deleted on Chromosome 10) is a 3’ phosphoinositide phosphatase that converts PI(3,4,5)P3 to PI(4,5)P2 thus opposing PKB/Akt activation by PI 3-K. Pretreatment of neutrophils with SF1670 leads to enhanced fMLP-1 induced PI(3,4,5)P3 signaling effects such as Akt phosphorylation, NADPH oxidase-mediated superoxide formation, cell polarization, chemotactic migration, and phagocytosis. SF1670 also inhibits CD45 (IC50 = 200 nM).

Storage

2-8°C

Related Products:

PTEN Enzyme (E-3000)
PTEN Activity ELISA (K-4700)
Malachite Green Assay Kit (K-1500)
PTEN Substrates: P-3908, P-3916, Q-1345
Other Lipid Phosphatases: SHIP2 (E-1000), INPP4A (E-8000)


Options/Sizes Pricing
B-0350-1mg $ 45.00
B-0350-5mg $ 115.00
B-0350-10mg $ 195.00
Additional Information:
Tech Data Sheet - TDS_B-0350_rev1


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assay and reagents for drug discovery in lipid signaling pathways