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VO-OHpic (PTEN Inhibitor)


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Catalog No.:  B-0351
MW: 415.2
CAS: 476310-60-8

Description:  The vanadium complex VO-OHpic is a potent, reversible, allosteric inhibitor of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) which hydrolyzes the 3-phosphate from phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3, formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. VO-OHpic is reported to be selective for PTEN (IC50~35 nM) compared with other cysteine-based phosphatases (PTPβ, SAC, MTM, & SopB, IC50>4 μM). Treatment of insulin-stimulated NIH 3T3 and L1 fibroblasts caused an increase in Akt-phosphorylation indicating inhibition of PTEN in vivo.

Storage

-20 °C

Related Products

PTEN enzyme (E-3000)
PTEN Activity ELISA (K-4700)
Malachite Green Assay Kit (K-1500)
PTEN Substrates: P-3908, P-3916, Q-1345
SF1670 (PTEN Inhibitor) (B-0350)
Other Lipid Phosphatases: SHIP2 (E-1000), INPP4A (E-8000)


Options/Sizes Pricing
B-0351-5mg $ 88.00
B-0351-10mg $ 140.00
B-0351-25mg $ 290.00
Additional Information:
Tech Data Sheet - TDS_B-0351_rev1


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assay and reagents for drug discovery in lipid signaling pathways