S1P Lyase Fluorogenic Substrate

Catalog No.:  S-200U
MW: 376.3
Purity: >95%
CAS: 1166838-84-1

Description:  Sphingosine-1-phosphate lyase (S1PL) is an enzyme that breaks sphingosine-1-phosphate into hexadecenal and phosphoethanolamine. S1PL has been proposed as a target for autoimmune disorder treatment and in cancer therapy. The S1PL fluorogenic substrate is intended for monitoring S1PL activity releasing fluorescent 7-hydroxycoumarin in the presence of active enzyme.


-20°C or below.


1. Billich, A., et al. (2013). "Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis." PLoS One 8(3): e59630.
2. Engel, N., et al. (2012). "Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A." PLoS One 7(10): e47833.
3. Bedia, C., et al. (2009). "Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity." Chembiochem 10(5): 820-2.

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Options/Sizes Pricing
S-200U-1mg $ 294.00
S-200U-5mg $ 1,260.00
S-200U-10mg $ 2,415.00
Additional Information:
Tech Data Sheet - TDS_S-200U_Rev.2

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assay and reagents for drug discovery in lipid signaling pathways