Products

Fosmidomycin


Zoom
 
Catalog No.:  B-4201
MW: 205.08
Purity: >95%
CAS: 66508-53-0

Description:  Fosmidomycin is a naturally occurring antibiotic that inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), an enzyme in the non-mevanolate pathway for isoprenoid biosynthesis. The non-mevanolate, or MEP, pathway is essential in gram-negative, some gram-positive bacteria, plants, and protozoa making it an attractive pathway to target for antibiotics since mammals use the mevalonate pathway to synthesize isoprenoids. Fosmidomycin has been tested in humans against Plasmodium falciparum (malaria) and shown to be effective.

Storage

-20°C or below

References

1) E. Iguchi, et al. “Studies on new phosphonic acid antibiotics. II. Taxonomic studies on producing organisms of the phosphonic acid and related compounds” The Journal of Antibiotics 33, 1980, 19–23.
2) B. Lell, et al. “Fosmidomycin, A Novel Chemotherapeutic Agent for Malaria” Antimicrob Agents Chemother. 57, 2003, 735-738.
3) T. Umeda, et al. “Molecular Basis of Fosmidomycin’s action on the Human Parasite Plasmodium falciparum” Sci. Rep., 1, 2011, doi:10.1038/srep00009.

Keywords: [3-(N-hydroxyformamido)-propyl)phosphonate) sodium salt], Malaria, non-mevalonate, MEP, DXR


Options/Sizes Pricing
B-4201-5mg $ 81.00
B-4201-25mg $ 205.00
Additional Information:
Tech Data Sheet - B-4201


Add a specific quantity to your cart    *  


Back to the webstore startpage      Back to the product overview      Your Shopping Cart      Terms of Service


assay and reagents for drug discovery in lipid signaling pathways