Catalog No.:  B-0051
MW: 628.72
CAS: 57444-62-9

Resiniferotoxin is a glass-like resin diterpene ester and a component of many Euphorbiacea species. It is a powerful skin irritant and a potent analog of capsaicin, the active principle in hot peppers, and approximately 1000 times more potent. It is used as an agonist of the Transient receptor potential cation channel subfamily V member 1 (TrpV1) receptor, also known as the capsaicin receptor and the vanilloid receptor 1, in biochemical, cellular, and pharmacological studies related to pain and nocioception.


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1) Zhou, H, Chen, S, Chen, H, Pan, H, "Sustained inhibition of neurotransmitter release from nontransient receptor potential vanilloid type 1-expressing primary afferents by ?-opioid receptor activation-enkephalin in the spinal cord" Journal of Pharmacology and Experimental Therapeutics (2008), 327(2), 375-382. DOI:10.1124/jpet.108.141226.
2) Mishra, S, Hoon, M, "Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation" Molecular and Cellular Neuroscience (2010), 43(1), 157-163. DOI:10.1016/j.mcn.2009.10.006
3) Stevenson, Graeme I, et al,"4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure-Activity Relationships and in Vivo Activity" Journal of Medicinal Chemistry (1998), 41(23), 4623-4635. DOI:10.1021/JM980376B
4) Ossipov, M, Lai, Malan, T, Porreca, F, "Spinal and supraspinal mechanisms of neuropathic pain" Annals of the New York Academy of Sciences (2000), 909(New Medications for Drug Abuse), 12-24.
5) Marotta, D et al, "Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw" Biochemical Pharmacology (2009), 77(7), 1223-1235. DOI:10.1016/j.bcp.2008.12.025

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B-0051-1mg $ 55.00
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Tech Data Sheet - TDS_B-0051_Rev1

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assay and reagents for drug discovery in lipid signaling pathways