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IspF Inhibitor 1


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Catalog No.:  B-4102
MW: 584.3
Purity: 97%
CAS: 1240789-72-3

The non-mevalonate, or MEP, pathway for isoprenoid biosynthesis is essential in gram-negative, some gram-positive bacteria, plants, and protozoa making it an attractive pathway to target for antibiotics since mammals use the mevalonate pathway to synthesize isoprenoids. IspF is the fourth step in the pathway and converts diphosphocytidyl-2-methylerythritol 2-phosphate into 2-methylerythritol 2,4-cyclodiphosphate (cMEPP). IspF inhibitor 1 (compound 3 in Geise et al.) has low micromolar activity (IC50 = 6.1-32 μM) against the recombinant enzymes and inhibits the growth of P. falciparum in a red blood cell assay.

Storage

4°C or below

Reference

J.G. Geist et al “Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacteriumtuberculosis and Plasmodium falciparum” ChemMedChem 2010, 5, 1092-1101.


Options/Sizes Pricing
B-4102-5mg $ 103.00
B-4102-10mg $ 189.00
B-4102-25mg $ 406.00
Additional Information:
Tech Data Sheet - TDS_B-4102_rev1


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assay and reagents for drug discovery in lipid signaling pathways