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PI4-Kinase II beta (PI4KIIb), active


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Catalog No.:  P22-10G

Description:  Description: Full-length recombinant human PI4KIIB was co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Enzyme obtained from SignalChem.


Molecular weight: ~84 kDa

Sequence: Full length

Species: Human

Tag: GST tag

Purity: >90 % (see TDS for lot specific information)

Specific Activity: >30 nmol/min/mg (see TDS for lot specific information)

Expression System: Sf9 insect cells using baculovirus

Genebank Number: NM_018323

Applications: PI 4-Kinase assay , western blot.

Formulation: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Storage and stability: Store product at -70ÂșC. Stable up to one year.


Scientific Background: PI4KIIB is a member of the phosphatidylinositol 4-kinase family (PI4K) that phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate which are immediate precursor of several important signaling and scaffolding molecules. PI4KIIB is primarily a cytosolic PI4K that is recruited to membranes where it stimulates phosphatidylinositol 4,5-bisphosphate syntheses. PI4KIIB uses phosphatidylinositol as their primary substrate and has no activity on phosphatidylinositol monophosphates. PI4KIIB is a restricted minor histocompatibility antigen in patients that had been successfully treated with donor lymphocyte infusions for relapsed chronic myeloid leukemia after allogeneic stem cell transplantation.



related products:

PI(4)P Mass ELISA (K-4000E)

PI 4-Kinase Activity ELISA (K-4000K)

PIk-93; PI 4-kinase Inhibitor (B-0306)

PI4KIIIa (P21-10G)

PI4KIIIb (P-22-10G)





Options/Sizes Pricing
P22-10G-5ug $ 205.00
P22-10G-10ug $ 295.00

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assay and reagents for drug discovery in lipid signaling pathways