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VPC23019 (S1P1/3 Antagonist)


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Catalog No.:  B-0061
MW: 372.18
CAS: 449173-19-7

Description: 

Sphingosine-1-phosphate (S1P) is a versatile signaling molecule, which is produced by phosphorylation of sphingosine by two distinct sphingosine kinases, SphK1 and SphK2. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation, motility, survival, and has a role in regulation cell shape and Ca2+ homeostasis. VPC23019, an analog of FTY720 (Fingolimod, Gilenya), is a potent anatagonist of the S1P1 & S1P3 receptors. VPC23019 will inhibit the migration of various types of cancer cells.

Storage

-20 °C or below

References

1) M. D. Davis, J. J. Clemens, T. L. Macdonald, et al. “Sphingosine 1-phosphate analogs as receptor antagonists.” The Journal of Biological Chemisty, 280 (2005), 9833-9841.
2) R.J. Watters, H-G. Wang, et al. “Targeting Sphingosine-1-Phosphate Receptors in Cancer” Anticancer Agents Med Chem., 11 (2011), 810-817.


Options/Sizes Pricing
B-0061-1mg $ 49.00
B-0061-5mg $ 175.00
B-0061-10mg $ 250.00
Additional Information:
Tech Data Sheet - TDS_B-0061_Rev 1


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assay and reagents for drug discovery in lipid signaling pathways