K149 (SHIP2 Inhibitor)

Catalog No.:  B-0345
MW: 414.81
CAS: 1071547-54-1

Description:  SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. PI(3,4)P2 activates Protein Kinase B (PKB/Akt) and promotes cell survival. SHIP2 expression and activity is increased in colorectal cancer suggesting an oncogenic role. Treatment of colorectal cancer cells with K149 (2uM) decreases PKB/Akt signaling and sensitizes the cells to 5-fluorouracil regardless of whether the cell lines have a PI3KCA mutation.


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1) E. Hoekstra, A.H. Das, et al. “Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation” Oncotarget 2016; 7:73525-73540. DOI: 10.18632/oncotarget.12321

Related Products:

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3-α-Aminocholestane (3AC, SHIP1 Inhibitor) (B-0341)
SHIP2 active enzyme (E-1000)
5'- PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay (K-1400)

Options/Sizes Pricing
B-0345-5mg $ 100.00
B-0345-10mg $ 173.00
Additional Information:
Tech Data Sheet - TDS_B-0345_rev1

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assay and reagents for drug discovery in lipid signaling pathways