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Geranylgeranyl Diphosphate (GGPP)


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Catalog No.:  I-0200
MW: 501.53
CAS: 104715-21-1

Description:  Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway.

Provided as the tris-ammonium salt

Storage

-20°C or below.

featured in Publications

1) Gibot, L., J. Follet, et al. (2009). "Human caspase 7 is positively controlled by SREBP-1 and SREBP-2." Biochem J 420(3): 473-83.
2) Lai, D., B. Lluncor, et al. (2009). "Reconstruction of the archaeal isoprenoid ether lipid biosynthesis pathway in Escherichia coli through digeranylgeranylglyceryl phosphate." Metabolic Engineering 11(3): 184.
3) Zhou, X.-P., K.-Y. Wu, et al. (2008). "TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis." Proceedings of the National Academy of Sciences 105(44): 17181-17186.
4) Gruenbacher, G., H. Gander, et al. (2010). "IL-2 costimulation enables statin-mediated activation of human NK cells, preferentially through a mechanism involving CD56+ dendritic cells." Cancer Res 70(23): 9611-20.

Product Keywords: Geranylgeranyl pyrophosphate, GGPP

Bulk discounts available, please email echelon@echelon-inc.com for information.


Options/Sizes Pricing
I-0200-1mg $ 150.00
I-0200-10mg $ 920.00
Additional Information:
Tech Data Sheet - I-0200


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