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(3S)-[1,1-difluoro-3,4-bis(oleoyloxy)butyl] phosphonate (XY-14)


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Catalog No.:  L-9218
MW: 778.94
CAS: 478529-66-7

Description:  XY-14 is a competitive inhibitor of Lipid Phosphate Phosphatase 1 (LPP1) which is the major enzyme responsible for degrading lysophosphatidic acid (LPA) in platelets. XY-14 (10 μM) inhibits LPP1 in human pulmonary artery endothelial cells, preventing the dephosphorylation of sphingosine 1-phosphate (S1P) to sphingosine.

Storage

  • -20 °C

Featured in Publications

1) Smyth, S. S., V. A. Sciorra, et al. (2003). "Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets." Journal of Biological Chemistry 278(44): 43214-43223.
2) Zhao, Y., S. K. Kalari, et al. (2007). "Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells: Role Of Lipid Phosphate Phosphatase-1 And Sphingosine Kinase 1." J Biol Chem 282(19): 14165-77.


Options/Sizes Pricing
L-9218-0.5mg $ 349.00
L-9218-1mg $ 662.00
Additional Information:
Tech Data Sheet - TDS_L-9218_ Rev 6


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assay and reagents for drug discovery in lipid signaling pathways