Products

L-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2S-OMPT)


Zoom
 
Catalog No.:  L-9418
MW: 452.63
CAS: 645408-61-3

Description:  OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers, (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release, IL-6 production, and MAPK and Akt phosporylation in OVCAR3 cells.

Storage

-20 °C

Featured in Publication

<1) Lin, D. A. and J. A. Boyce (2005). "IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells." J Immunol 175(8): 5430-8.
2) Zhao, C., M. J. Fernandes, et al. (2008). "Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?" Mol Pharmacol 73(2): 587-600.
3) Qian, L., Y. Xu, et al. (2003). "Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity." J Med Chem 46(26): 5575-8.


Options/Sizes Pricing
L-9418-0.5mg $ 54.00
L-9418-5mg $ 254.00
Additional Information:
Tech Data Sheet - L-9418


Add a specific quantity to your cart    *  


Back to the webstore startpage      Back to the product overview      Your Shopping Cart      Terms of Service


assay and reagents for drug discovery in lipid signaling pathways