L-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2S-OMPT)

Catalog No.:  L-9418
MW: 466.61
CAS: 645408-61-3

Description:  OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers, (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release, IL-6 production, and MAPK and Akt phosporylation in OVCAR3 cells.


-20 °C

Featured in Publication

1) Lin, D. A. and J. A. Boyce (2005). "IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells." J Immunol 175(8): 5430-8.
2) Zhao, C., M. J. Fernandes, et al. (2008). "Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?" Mol Pharmacol 73(2): 587-600.
3) Qian, L., Y. Xu, et al. (2003). "Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity." J Med Chem 46(26): 5575-8.

Options/Sizes Pricing
L-9418-0.5mg $ 63.00
L-9418-5mg $ 390.00
Additional Information:
Tech Data Sheet - TDS_L-9418_Rev 2

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assay and reagents for drug discovery in lipid signaling pathways