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Purified Anti-PtdIns (4,5)P2 IgM


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Catalog No.:  Z-P045

Description:  Purified Anti-PtdIns(4,5)P2 monoclonal antibody.
Subclass: IgM
Source: Mouse
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay (PIP Strip)

Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times

Featured in Publications

1) Terebiznik, M. R., O. V. Vieira, et al. (2002). "Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella." Nat Cell Biol 4(10): 766-73.
2) Hirono, M., C. S. Denis, et al. (2004). "Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation." Neuron 44(2): 309-20.
3) Leloup, L., H. Shao, et al. (2010). "m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate." Journal of Biological Chemistry 285(43): 33549-33566.

Related Products

Anti-PtdIns(4,5)P2 IgM in cell supernatant (Z-S045)
Anti-PtdIns(4,5)P2 IgM In Ascites (Z-A045)
Biotinylated Anti-PtdIns(4,5)P2 IgM (Z-B045)
Fluorescein conjugated Anti-PI(4,5)P2 IgM (Z-G045)
Anti-PtdIns(4,5)P2 IgM HRP (Z-H045)

Product keywords: PIP2, PI(4,5)P2, PtdIns(4,5)P2, IgM, anti-PIP2


Options/Sizes Pricing
Z-P045-10ug $ 130.00
Z-P045-50ug $ 345.00
Z-P045-250ug $ 1,578.00
Additional Information:
Tech Data Sheet - Z-P045

Protocol - Protocol for immunofluorescence in chamber slides

Protocol b - Protocol for frozen tissue sections


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assay and reagents for drug discovery in lipid signaling pathways