Products

Biotinylated Anti-PtdIns(3,4,5)P3 IgM

 
Catalog No.:  Z-B345

Description:  Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody conjugated with biotin.
Subclass: IgM
Source: Mouse
Applications: ELISA, Immunofluorescence

Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Anzelon, A. N., H. Wu, et al. (2003). "Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function." Nat Immunol 4(3): 287-94.
2) Verkoczy, L., B. Duong, et al. (2007). "Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection." J Immunol 178(10): 6332-41.
3) Rotman, T., N. Etkovitz, et al. (2010). "PKA and PKC{alpha}/PP1{gamma}2 play opposing roles in the regulation of PI3K activation in bovine sperm." Reproduction: REP-09-0314.

Related Products

Purified Anti-PtdIns(3,4,5)P3 IgM (Z-P345)
Fluorescein conjugated Anti-PI(3,4,5)P3 IgM (Z-G345)
Anti-PtdIns(3,4,5)P3 IgM HRP (Z-H345)
Purified Anti-PtdIns(3,4,5)P3 IgG (Z-P345b)

Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3


Options/Sizes Pricing
Z-B345-10ug $ 201.00
Z-B345-50ug $ 381.00
Additional Information:
Tech Data Sheet - Z-B345

Protocol - Protocol for immunofluorescence in chamber slides

Protocol - Protocol for frozen tissue sections


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assay and reagents for drug discovery in lipid signaling pathways