Phosphatidylinositol 3,5-bisphosphate diC16 (PI(3,5)P2 diC16)

Catalog No.:  P-3516
MW: 1080.9
CAS: 214282-36-7

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).



Featured in Publications:

1) Ikonomov, O. C., D. Sbrissa, et al. (2002). "Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity." J Biol Chem 277(11): 9206-11.
2) Merlot, S., R. Meili, et al. (2003). "A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi." J Biol Chem 278(41): 39866-73.

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Product Keywords: Dipalmitoyl Phosphatidylinositol 3,5-bisphosphate, PtdIns(3,5)P2 C16, PI(3,5)P2 C16

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Options/Sizes Pricing
P-3516-100ug $ 50.00
P-3516-500ug $ 236.00
P-3516-1mg $ 422.00
Additional Information:

Tech Data Sheet - TDS_P-3504, P-3508, P-3516_ Rev 7

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assay and reagents for drug discovery in lipid signaling pathways