Phosphatidylinositol 4,5-bisphosphate diC8 (PI(4,5)P2 diC8)

Catalog No.:  P-4508
MW: 856.48
CAS: 204858-53-7

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K).


-20 °C

Featured in Publications

1) Jenco, J. M., A. Rawlingson, et al. (1998). "Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins." Biochemistry 37(14): 4901-9.
2) Campbell, R. B., F. Liu, et al. (2003). "Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate." J Biol Chem 278(36): 33617-20.
3) Haider, S., A. I. Tarasov, et al. (2007). "Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis." EMBO J 26(16): 3749.
4) Lewis, A. E., L. Sommer, et al. (2011). "Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction." Mol Cell Proteomics 10(2): M110 003376.

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Product Keywords: Dioctanoyl Phosphatidylinositol 4,5-bisphosphate, PtdIns(4,5)P2 C8, PI(4,5)P2 C8, or PIP2

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Options/Sizes Pricing
P-4508-100ug $ 42.00
P-4508-500ug $ 184.00
P-4508-1mg $ 341.00
P-4508-5mg $ 2,494.00
Additional Information:

Tech Data Sheet - P-4508 TDS

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assay and reagents for drug discovery in lipid signaling pathways