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Phosphatidylinositol 4,5-bisphosphate diC16 (PI(4,5)P2 diC16)


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Catalog No.:  P-4516
MW: 1080.9
CAS: 120595-88-2

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K).

Storage

-20° C

Featured in Publications:

1) Hodgkin, M. N., M. R. Masson, et al. (2000). "Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain." Curr Biol 10(1): 43-6.
2) Ozaki, S., D. B. DeWald, et al. (2000). "Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers." Proc Natl Acad Sci U S A 97(21): 11286-11291.
3) Gwanyanya, A., K. R. Sipido, et al. (2006). "ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes." Am J Physiol Cell Physiol 291(4): C627-35.
4) Liu, Z., T. Klaavuniemi, et al. (2011). "Distinct roles of four gelsolin-like domains of Caenorhabditis elegans gelsolin-like protein-1 in actin filament severing, barbed end capping, and phosphoinositide binding." Biochemistry 49(20): 4349-60.

Product Keywords: Dipalmitoyl Phosphatidylinositol 4,5-bisphosphate, PtdIns(4,5)P2, PI(4,5)P2, or PIP2

Bulk discounts available, please email echelon@echelon-inc.com for information.


Options/Sizes Pricing
P-4516-100ug $ 47.00
P-4516-500ug $ 218.00
P-4516-1mg $ 390.00
Additional Information:
PIP FAQ - PIP FAQ's

Tech Data Sheet - P-4516 TDS


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assay and reagents for drug discovery in lipid signaling pathways