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1-Deoxy-D-xylulose 5-phosphate (DXP)


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Catalog No.:  I-M050
MW: 258.07
CAS: 190079-18-6

Description:  Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 1-Deoxy-D-xylulose 5-phosphate (DXP) is an intermediate in the non-mevalonate pathway and is formed from pyruvate and glyceraldehyde 3-phosphate by DXP synthase. It is converted to MEP by MEP Synthase (DXP reductoisomerase).

Provided as the sodium salt

Storage

-20°C or below

Featured in Publications:

1) Poliquin, K., Y. V. Ershov, et al. (2004). "Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro." J Bacteriol 186(14): 4685-4693.
2) Gottlin, E. B., R. E. Benson, et al. (2003). "High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition." J Biomol Screen 8(3): 332-9.
3) Bailey, A. M., S. Mahapatra, et al. (2002). "Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase." Glycobiology 12(12): 813-20.

Keywords: 1-Deoxy-D-xylulose 5-phosphate, 1-Deoxyxylulose 5-phosphate, Deoxyxylulose phosphate, DOXP, DXP

Bulk discounts available, please email echelon@echelon-inc.com for information.


Options/Sizes Pricing
I-M050-1mg $ 72.00
I-M050-5mg $ 281.00
I-M050-10mg $ 552.00
Additional Information:
Tech Data Sheet - TDS_I-M050_v5


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