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AS605240 (PI3-K gamma Inhibitor 1)


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Catalog No.:  B-0301
MW: 257.3
Purity: 95%
CAS: 648450-29-7

Description:  5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione (AS605240) is an ATP-competitive inhibitor of PI3-Kγ (IC50 = 8 nM). It is selective for the γ-isoform (IC50: PI 3-Kα = 60 nM, PI 3-Kβ = 270 nM, PI 3-Kδ = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 μM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus.

Solubility

  • water: insoluble, DMSO: 2.5 mg/mL

Storage

  • store dry between 2-8oC. Stock solutions should be stored frozen (-20oC).

References

1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of
rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943.

2) D.F. Barber, et al., "PI3Kg inhibition blocks
glomerulonephritis and extends lifespan in a mouse model of systemic lupus" Nature Medicine, 2005, 11, 933-935.


Options/Sizes Pricing
B-0301-1mg $ 23.00
B-0301-5mg $ 52.00
Additional Information:
Tech Data Sheet - B-0301


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