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AS604850 (PI3-K gamma Inhibitor 2)


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Catalog No.:  B-0302
MW: 287.2
Purity: 99%
CAS: 648449-76-7

Description:  5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-
Kγ with an IC50 = 250 nM. AS604850 is selective for the γ-isoform (IC50: PI 3-Kα = 4.5 μM, PI 3-Kβ, PI 3-Kδ > 20 μM) and
shows no notable activity against a wide array of protein kinases at 1 μM.

Solubility

  • water: insoluble, DMSO: 5 mg/mL

Storage

  • store dry between 2-8oC. Stock solutions should be stored frozen (-20oC).

References

1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of
rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943.


Options/Sizes Pricing
B-0302-1mg $ 23.00
B-0302-5mg $ 104.00
Additional Information:
Tech Data Sheet - B-0302


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assay and reagents for drug discovery in lipid signaling pathways