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PI3-K alpha Inhibitor 2


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Catalog No.:  B-0304
MW: 313.4
Purity: 98%
CAS: 371943-05-4

Description:  3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol is a selective inhibitor for the α-isoform of PI 3-Kinase (IC50: PI 3-Kα = 2 nM, PI 3-Kβ = 16 nM, PI3-Kγ = 660 nM, PI3KC2β = 220 nM)). It showed >1000-fold selectivity vs. protein kinases such as PKA, KDR, PKCa, and E/CDK2 (IC50 = 91, 3.4, 466, 288 μM). It inhibited proliferation of A375 melanoma cells at 580 nM.

Solubility

water: insoluble, DMSO: 10 mg/mL

Storage

store dry at 4oC. Stock solutions should be stored frozen (-20oC).

References

1) M. Hayakawa, et al. "Synthesis and biological evaluation of 4-morpholino-2-phenyl
quinazolines and related derivatives as novel PI3 kinase p110a inhibitors" Bioorg. Med. Chem. 2006, 14, 6847-6858.


Options/Sizes Pricing
B-0304-1mg $ 43.00
B-0304-5mg $ 184.00
Additional Information:
Tech Data Sheet - B-0304


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assay and reagents for drug discovery in lipid signaling pathways