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Akt Inhibitor (FPA-124)


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Catalog No.:  B-0101
MW: 381.7
Purity: 99%
CAS: 902779-59-3

Description:  FPA-124 is a cell-permeable inhibitor of Akt (IC50 = 100 nM), binding to the PH and kinase domains. It inhibits cell proliferation in Colo357, BxPC3, BT20, and PC3 cancer cell lines with IC50 values ranging from 7-55 nM. FPA-124 inhibited tumor growth in mice with negligible toxicity.

Solubility

DMSO: 5 mg/mL

Storage

Store dry between 2-8oC. Stock solutions should be stored frozen (-20oC).

References

1) V. Barve, et al. "Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic
Derivatives of Chromen-4-one in Human Cancer Cells" J. Med. Chem., 2006, 49, 3800-3808.

2) Biscetti, F., G. Straface, et al. (2009). "Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation." Cardiovasc Diabetol 8: 49.
3) Brito, P. M., R. l. Devillard, et al. (2009). "Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells." Atherosclerosis 205(1): 126.


Options/Sizes Pricing
B-0101-5mg $ 70.00
Additional Information:
Tech Data Sheet - B-0101


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assay and reagents for drug discovery in lipid signaling pathways