Products

Akt Inhibitor (KP372-1)


Zoom
 
Catalog No.:  B-0102
MW: 224.2
Purity: 95%
CAS: 329710-24-9

Description:  KP372-1 directly inhibits the kinase activities of Akt, PDK1 and Flt3 (Fms-like tyrosine kinase 3), which are aberrantly activated in acute myelogenous leukemia (AML). It is a cell permeant inhibitor that decreases the colony-forming ability of AML cells (IC50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma.

Solubility

Water: insoluble, DMSO: 5 mg/mL

Storage

dry between 2-8oC. Stock solutions should be stored frozen (-20oC).

References

1) M. Mandal et al. "The Akt Inhibitor KP372-1 Suppresses Akt Activity and Cell Proliferation and Induces
Apoptosis in Thyroid Cancer Cells" Br. J. Cancer, 2005, 92, 1899-1905.

2) Z. Zeng et al "Simultaneous Inhibition of
PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial
Dysfunction and Apoptosis in Acute Myelogenous Leukemia." Cancer Res., 2006, 66, 3737-3746.


Options/Sizes Pricing
B-0102-1mg $ 65.00
B-0102-5mg $ 284.00
Additional Information:
Tech Data Sheet - TDS_B-0102_v2


Add a specific quantity to your cart    *  


Back to the webstore startpage      Back to the product overview      Your Shopping Cart      Terms of Service


assay and reagents for drug discovery in lipid signaling pathways