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(3S)-1-fluoro-3-hydroxy-4-butyl-1-phosphonate (XY-17)


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Catalog No.:  L-9118
MW: 490.5
CAS: 565438-23-5

Description:  XY-17 is a fluorinated phosphonate analog of lysophosphatidic acid (LPA). XY-17 is not hydrolyzed by lipid phosphate phosphatase (LPP) and acts as an agonist of the LPA3 receptor.

Storage

-20 °C

Featured in Publications:

1) Xu, Y., M. Tanaka, et al. (2004). "Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors." Bioorg Med Chem Lett 14(21): 5323-8.
2) Zhao, Y., P. V. Usatyuk, et al. (2005). "Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells." Biochem. J. 385(2): 493-502.
3) Prestwich, G., Y. Xu, et al. (2005). "New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors." Biochem Soc Trans 33: 1357–1361.


Options/Sizes Pricing
L-9118-0.5mg $ 277.00
Additional Information:
Tech Data Sheet - L-9118


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assay and reagents for drug discovery in lipid signaling pathways